• Product NameExemestane
• Brief DescriptionInhibitors
• Purification99.35%
• Biological ActivityExemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast Y in postmenopausal women. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation.
• Target NameAromatase inhibitor
• CAS No. 107868-30-4
• Calculated MW 296.4
• Formulation C20H24O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CC(=C)C4=CC(=O)C=C[C@]34C
  Pathways:Endocrinology/Hormones
  Receptor:Aromatase (human); Aromatase (rat)
  Boling pt:
  Melting pt:155.13C
  Solubility:Ethanol: 15 mg/mL (50.6 mM); DMSO: 54 mg/mL (182.18 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wang X, et al. Y Res, 2006, 66(21), 10281-10286.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting