• Product NameEzetimibe
• Brief DescriptionInhibitors
• Purification97.28%
• Biological ActivityEzetimibe is an anti-hyperlipidemic medication which is used to lower cholesterol levels. Specifically, it appears to bind to a critical mediator of cholesterol absorption, the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells as well as in hepatocytes.
• Target NameNPC1L1 inhibitor; Nrf2 inhibitor; Others
• CAS No. 163222-33-1
• Calculated MW 409.43
• Formulation C24H21F2NO3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O
  Pathways:Immunology/Inflammation; Membrane transporter/Ion channel; Others
  Receptor:NPC1L1; Nrf2; Sterol O-acyltransferase
  Boling pt:
  Melting pt:164-166C
  Solubility:DMSO: 81mg/ml(197.85 mM);Water: <1mg/ml;Ethanol: 81mg/ml(197.85 mM)
  Appearance:White Crystal
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Singh A, et al. J Ind Microbiol Biotechnol. 2009 Nov;36(11):1369-74.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting