• Product NameFasudil
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityFasudil hydrochloride (INN) is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage, as well as to improve the cognitive decline seen in stroke victims. It has been found to be effective for the treatment of pulmonary hypertension.
• Target NamePKA inhibitor; PKC inhibitor; ROCK inhibitor; Serine/threonin kinase inhibitor
• CAS No. 103745-39-7
• Calculated MW 291.37
• Formulation C14H17N3O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:O=S(=O)(N1CCC[NH2+]CC1)C1=CC=CC2=C1C=CN=C2
  Pathways:Cell Cycle/Checkpoint; Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells
  Receptor:PKA; PKG; PKC; ROCK2; MLCK
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hu H, et al. Exp Mol Pathol. 2015 Apr;98(2):277-85.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting