• Product NameIrbesartan
• Brief DescriptionInhibitors
• Purification99.81%
• Biological ActivityIrbesartan is an angiotensin receptor blocker (ARB) used mainly for the treatment of hypertension. It competes with angiotensin II for binding at the AT1 receptor subtype. Unlike ACE inhibitors, ARBs do not have the adverse effect of dry cough. The use of ARBs is pending revision due to findings from several clinical trials suggesting that this class of drugs may be associated with a small increased risk of Y.
• Target NameRAAS inhibitor
• CAS No. 138402-11-6
• Calculated MW 428.54
• Formulation C25H28N6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:CCCCC1=NC2(CCCC2)C(=O)N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NNN=N1
  Pathways:Endocrinology/Hormones
  Receptor:AT1 receptor
  Boling pt:648.6C
  Melting pt:180-181C
  Solubility:Ethanol: 3 mg/mL (7.0 mM); DMSO: 1 mg/mL (2.33 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bernhart CA, et al. J Med Chem, 1993, 36(22), 3371-3380.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting