- Product NameImatinib Mesylate (STI571)
- Brief DescriptionInhibitors
- Purification98.00%
- Biological ActivityImatinib mesylate is a tyrosine kinase inhibitor IC50 value of 100 nM, 100 nM, 600 nM for v-Abl, c-kit, PDGFR, respectively . Tyrosine kinase is an enzyme which is a subclass of protein kinase and plays an important role in transferring a phosphate group from ATP to a protein in cells. It is shown that tyrosine kinase plays a pivotal role in the management of disorders in which activation of c-Abl, PDGFR, or c-Kit signaling. Recently, the role of tyrosine kinases in the modulation of growth factor signaling are received more and more attention and gradually become an especial important target.
- Target NameBcr-Abl inhibitor; c-Kit inhibitor; PDGFR inhibitor
- CAS No. 220127-57-1
- Calculated MW 589.71
- Formulation C29H31N7OCH4SO3
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
