• Product NameAmbrisentan
• Brief DescriptionInhibitors
• Purification99.65%
• Biological ActivityAmbrisentan(BSF 208075; LU 208075) is an oral, once-daily endothelin receptor antagonist that is selective for the endothelin type A receptor.
• Target NameEndothelin Receptor antagonist
• CAS No. 177036-94-1
• Calculated MW 378.42
• Formulation C22H22N2O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=CC(=NC(=N1)O[C@H](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
  Pathways:GPCR/G Protein
  Receptor:ET-A
  Boling pt:551.1C?
  Melting pt:>150C?
  Solubility:Ethanol: 22 mg/mL (58.13 mM); DMSO: 76 mg/mL (200.83 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Vatter H, Seifert V. Cardiovasc Drug Rev. 2006 Spring;24(1):63-76.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting