- Product NameVandetanib (ZD6474)
- Brief DescriptionInhibitors
- Purification99.70%
- Biological ActivityVandetanib is an orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.
- Target NameEGFR inhibitor; VEGFR antagonist
- CAS No. 443913-73-3
- Calculated MW 475.31
- Formulation C22H24BrFN4O2
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
