• Product NameMeglutol
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityMEGLUTOL is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
• Target NameHMG-CoA Reductase inhibitor
• CAS No. 503-49-1
• Calculated MW 162.14
• Formulation C6H10O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:CC(O)(CC(O)=O)CC(O)=O
  Pathways:Metabolism
  Receptor:HMG-CoA reductase
  Boling pt:120C?
  Melting pt:105-108C
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Santarelli F, et al. Ital J Pediatr. 2013 May 24;39:33.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting