• Product NameTandutinib (MLN518)
• Brief DescriptionInhibitors
• Purification99.74%
• Biological ActivityTandutinib (MLN518, CT53518) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR.
• Target Namec-Kit inhibitor; CSF-1R inhibitor; FLT antagonist; PDGFR inhibitor; Src antagonist
• CAS No. 387867-13-2
• Calculated MW 562.7
• Formulation C31H42N6O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(OCCCN2CCCCC2)C=C2N=CN=C(N3CCN(CC3)C(=O)NC3=CC=C(OC(C)C)C=C3)C2=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:c-Kit; CSF-1R; FLT3; PDGFRβ; Src
  Boling pt:769.5C
  Melting pt:177-178C
  Solubility:Ethanol: 6 mg/mL (10.66 mM); DMSO: 5 mg/mL (8.88 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kelly LM, et al. Y Cell, 2002, 1(5), 421-432.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting