• Product NameMethacholine Chloride
• Brief DescriptionInhibitors
• Purification99.47%
• Biological ActivityMethacholine chloride is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
• Target NameAChR antagonist
• CAS No. 62-51-1
• Calculated MW 195.69
• Formulation C8H18ClNO2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:[Cl-].CC(C[N+](C)(C)C)OC(C)=O
  Pathways:Neuroscience
  Receptor:mAChR
  Boling pt:
  Melting pt:171-173C
  Solubility:DMSO: 42mg/mL
  Appearance:White Crystal
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Liu PS, et al. Eur J Pharmacol. 2011 Jan 10;650(1):34-40.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting