• Product NameY-27632 dihydrochloride
• Brief DescriptionInhibitors
• Purification99.97%
• Biological ActivityY-27632 2hydrochloride is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
• Target NameROCK inhibitor
• CAS No. 129830-38-2
• Calculated MW 320.26
• Formulation C14H21N3O2HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl
  Pathways:Cell Cycle/Checkpoint; Stem Cells
  Receptor:ROCK1 (p160ROCK); ROCK2
  Boling pt:
  Melting pt:
  Solubility:Water: 14 mg/mL (43.71 mM); DMSO: 64 mg/mL warmed (199.83 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Uehata M, et al. Nature, 1997, 389(6654), 990-994.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting