• Product NameSB 431542
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivitySB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases.
• Target NameALK inhibitor
• CAS No. 301836-41-9
• Calculated MW 384.39
• Formulation C22H16N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:NC(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=CC=N1)C1=CC2=C(OCO2)C=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK5
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 3 mg/mL (7.8 mM); DMSO: 77 mg/mL (200.31 mM)
  Appearance:YellowPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Callahan JF, et al. J Med Chem, 2002, 45(5), 999-1001.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting