• Product NameAZD1080
• Brief DescriptionInhibitors
• Purification97.72%
• Biological ActivityAZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.
• Target NameGSK-3 inhibitor
• CAS No. 612487-72-6
• Calculated MW 334.37
• Formulation C19H18N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1COCCN1CC2=CN/C(=C\3/C4=C(C=CC(=C4)C#N)NC3=O)/C=C2
  Pathways:PI3K/Akt/mTOR signaling; Stem Cells
  Receptor:GSK-3α; GSK-3β
  Boling pt:
  Melting pt:
  Solubility:DMSO: 52 mg/mL (155.51 mM)
  Appearance:Red-Brown Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Georgievska B, et al. J Neurochem, 2013, 125(3), 446-456.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting