• Product Name4E1rcat
• Brief DescriptionInhibitors
• Purification98.00%
• Biological Activity4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.
• Target NamePERK inhibitor
• CAS No. 328998-25-0
• Calculated MW 478.45
• Formulation C28H18N2O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:C1=CC=C(C=C1)C2=C/C(=C\C3=CC=C(O3)C4=CC=C(C=C4)[N+](=O)[O-])/C(=O)N2C5=CC=C(C=C5)C(=O)O
  Pathways:Apoptosis
  Receptor:eIF-4E; eIF-4G
  Boling pt:
  Melting pt:
  Solubility:DMSO: 96 mg/mL (200.64 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shuda M, et al. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5875-82.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting