- Product NameD64131
- Brief DescriptionInhibitors
- Purification98.00%
- Biological ActivityD-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM. The polymerization of bovine brain tubulin as well as binding of [3H] colchicine to biotinylated αβ-tubulin was dose-dependently inhibited by D-64131. Many Y cells display abnormal microtubule structures, such as fragmented mitotic spindles or multiple spindle poles after treatment with D-64131. Nuclear blebbing and abnormal nuclear structures typical for apoptotic cells are detectable in many cells treated with D-64131. In nude mice, D-64131 proved to be well tolerated and highly active against the human amelanoic melanoma MEXF 989 tumor xenograft. D-64131 treatment resulted in significant tumor growth inhibition during treatment.
- Target NameMicrotubule Associated inhibitor
- CAS No. 74588-78-6
- Calculated MW 251.28
- Formulation C16H13NO2
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
