• Product NameZM 306416
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityZM 306416 is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM.
• Target NameBcr-Abl inhibitor; Src inhibitor; VEGFR inhibitor
• CAS No. 690206-97-4
• Calculated MW 333.74
• Formulation C16H13ClFN3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=C(OC)C=C2C(NC3=C(F)C=C(Cl)C=C3)=NC=NC2=C1
  Pathways:Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
  Receptor:Abl; Src; VEGFR1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 67 mg/mL (200.75 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Antczak C, et al. J Biomol Screen, 2012, 17(7), 885-899.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting