• Product NameML323
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityML323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively.
• Target NameDUB inhibitor
• CAS No. 1572414-83-5
• Calculated MW 384.48
• Formulation C23H24N6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC(C)C1=CC=CC=C1C1=NC=C(C)C(NCC2=CC=C(C=C2)N2C=CN=N2)=N1
  Pathways:Ubiquitination
  Receptor:USP1-UAF1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 38 mg/mL (98.83 mM); DMSO: 76 mg/mL (197.66 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Liang Q, et al. Nat Chem Biol. 2014 , 10(4), 298-304.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting