• Product NameSB525334
• Brief DescriptionInhibitors
• Purification98.39%
• Biological ActivitySB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.
• Target NameTGF-beta/Smad inhibitor
• CAS No. 356559-20-1
• Calculated MW 343.42
• Formulation C21H21N5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=CC=CC(=N1)C1=C(N=C(N1)C(C)(C)C)C1=CC2=NC=CN=C2C=C1
  Pathways:Stem Cells
  Receptor:TGFβR1(ALK5)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 68 mg/mL (198.0 mM); DMSO: 68 mg/mL (198.0 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Grygielko ET, et al. J Pharmacol Exp Ther, 2005, 313(3), 943-951.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting