• Product NameSB203580
• Brief DescriptionInhibitors
• Purification99.42%
• Biological ActivitySB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM.
• Target Namep38 MAPK inhibitor
• CAS No. 152121-47-6
• Calculated MW 377.43
• Formulation C21H16FN3OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CS(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1
  Pathways:MAPK
  Receptor:p38 MAPK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 43 mg/mL (113.92 mM)
  Appearance:YellowPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Ferdinand V. Lali, et al. J Biol Chem, 2000, 275(10), 7395-402.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting