• Product NamePardoprunox
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPardoprunox(SLV-308) is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist; D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A receptor (pKi = 8.5) full agonist (IA = 100%); also binds to D4 (pKi = 7.8), α1-adrenergic (pKi = 7.8), α2-adrenergic (pKi = 7.4), and 5-HT7 receptors (pKi = 7.2) with lower affinity.
• Target Name5-HT Receptor agonist; Adrenergic Receptor agonist; Dopamine Receptor agonist
• CAS No. 269718-84-5
• Calculated MW 233.27
• Formulation C12H15N3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CN1CCN(CC1)C1=CC=CC2=C1OC(=O)N2
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT1A; α2-adrenergic receptor; D2; D3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Pink Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Glennon JC, et al. Synapse. 2006 Dec 15;60(8):599-608.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting