• Product NameGNE9605
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGNE-9605 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 19 nM.
• Target NameLRRK2 inhibitor
• CAS No. 1536200-31-3
• Calculated MW 449.83
• Formulation C17H20ClF4N7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CNC1=NC(=NC=C1C(F)(F)F)NC2=C(N(N=C2)[C@H]3CCN(C[C@@H]3F)C4COC4)Cl
  Pathways:Autophagy
  Receptor:LRRK2; LRRK2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 12 mg/mL warmed (26.67 mM); DMSO: 89 mg/mL (197.85 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Estrada AA , et al. J Med Chem. 2014, 57(3), 921-936.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting