• Product NameSB 742457
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivitySB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.
• Target Name5-HT Receptor antagonist
• CAS No. 607742-69-8
• Calculated MW 353.44
• Formulation C19H19N3O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:O=S(=O)(C1=CC=CC=C1)C1=CN=C2C(C=CC=C2N2CCNCC2)=C1
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT6
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (5.65 mM); DMSO: 78 mg/mL (220.68 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chuang ATT, et al. Alzheimers Dement, 2006, 2, S631CS632 (abstract).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting