• Product NameNintedanib (BIBF 1120)
• Brief DescriptionInhibitors
• Purification99.65%
• Biological ActivityNintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM in cell-free assays. Phase 3.
• Target NameFLT inhibitor; Src inhibitor; VEGFR inhibitor
• CAS No. 656247-17-5
• Calculated MW 539.62
• Formulation C31H33N5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N/C(=C\3/C4=C(C=C(C=C4)C(=O)OC)NC3=O)/C5=CC=CC=C5
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FLT3; Lck; VEGFR1; VEGFR2; VEGFR3
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 3 mg/mL (5.55 mM); DMSO: 6 mg/mL (11.11 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hilberg F, et al. Y Res, 2008, 68(12), 4774-4782.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting