• Product NameAT 7519 hydrochloride salt
• Brief DescriptionInhibitors
• Purification99.90%
• Biological ActivityAT7519 hydrochloride is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM; is less potent to CDK3 and little active to CDK7.
• Target NameCDK inhibitor; GSK-3 inhibitor
• CAS No. 902135-91-5
• Calculated MW 418.71
• Formulation C16H18Cl3N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:Cl.CC1=C(C(=O)NC2=C(NN=C2)C(=O)NC2CCNCC2)C(Cl)=CC=C1
  Pathways:PI3K/Akt/mTOR signaling; Cell Cycle/Checkpoint; Stem Cells
  Receptor:CDK2/CyclinA; CDK4/CyclinD1; CDK5/p35; CDK9/CyclinT; GSK-3β
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 28 mg/mL warmed (66.87 mM); Water: 1 mg/mL warmed (2.38 mM); DMSO: 52 mg/mL warmed (124.19 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Squires MS, et al. Mol Y Ther, 2009, 8(2), 324-332.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting