• Product NameEPZ6438
• Brief DescriptionInhibitors
• Purification99.38%
• Biological ActivityEPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1403254-99-8
• Calculated MW 572.74
• Formulation C34H44N4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCN(C1CCOCC1)C1=CC(=CC(C(=O)NCC2=C(C)C=C(C)NC2=O)=C1C)C1=CC=C(CN2CCOCC2)C=C1
  Pathways:Chromatin/Epigenetic
  Receptor:EZH2; EZH2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 9 mg/mL (15.71 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Knutson SK, et al. Proc Natl Acad Sci U S A. 2013, 110(19), 7922-7927.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting