• Product NameFosaprepitant dimeglumine
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityFosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.
• Target NameNeurokinin 1 antagonist
• CAS No. 265121-04-8
• Calculated MW 1004.83
• Formulation C37H56F7N6O16P
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)N(N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
  Pathways:Neuroscience
  Receptor:NK1
  Boling pt:
  Melting pt:
  Solubility:Water: 135 mg/mL (134.35 mM); DMSO: 201 mg/mL (200.03 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Navari RM. Expert Opin Investig Drugs, 2007, 16(12), 1977-1985.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting