• Product NameRITA (NSC 652287)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityRITA(NSC 652287) induced both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks. RITA, a drug that, like nutlin-3, can disrupt the p53/Mdm2 interaction.
• Target NameMdm2 inhibitor; p53 inhibitor
• CAS No. 213261-59-7
• Calculated MW 292.37
• Formulation C14H12O3S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:OCC1=CC=C(S1)C1=CC=C(O1)C1=CC=C(CO)S1
  Pathways:Apoptosis
  Receptor:Mdm2; p53
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 8 mg/mL (27.36 mM); DMSO: 58 mg/mL (198.37 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ma T, et al. Biochem Biophys Res Commun. 2012, 417(3), 931-937.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting