• Product NameGW 788388
• Brief DescriptionInhibitors
• Purification98.79%
• Biological ActivityGW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, also inhibits TGF-(beta) type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.
• Target NameALK inhibitor
• CAS No. 452342-67-5
• Calculated MW 425.48
• Formulation C25H23N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:O=C(NC1CCOCC1)C1=CC=C(C=C1)C1=NC=CC(=C1)C1=C(NN=C1)C1=CC=CC=N1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK5
  Boling pt:
  Melting pt:
  Solubility:DMSO: 15 mg/mL (35.25 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gellibert F, et al. J Med Chem. 2006, 49(7), 2210-2221.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting