• Product NameGNF-5
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.220.1 uM (Wild type Abl).
• Target NameBcr-Abl inhibitor
• CAS No. 778277-15-9
• Calculated MW 418.37
• Formulation C20H17F3N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:OCCNC(=O)C1=CC=CC(=C1)C1=CC(NC2=CC=C(OC(F)(F)F)C=C2)=NC=N1
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:Bcr-Abl
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 20 mg/mL warmed (47.8 mM); DMSO: 83 mg/mL (198.38 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhang J, et al. Nature. 2010 Jan 28;463(7280):501-6.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting