• Product NameAtaluren (PTC124)
• Brief DescriptionInhibitors
• Purification99.84%
• Biological ActivityPTC124 (Ataluren) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation).
• Target NameCFTR inhibitor
• CAS No. 775304-57-9
• Calculated MW 284.24
• Formulation C15H9FN2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:OC(=O)C1=CC=CC(=C1)C1=NOC(=N1)C1=CC=CC=C1F
  Pathways:Membrane transporter/Ion channel
  Receptor:CFTR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 57 mg/mL (200.53 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Welch EM, et al. Nature, 2007, 447(7140), 87-91.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting