• Product NameAGI-6780
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.
• Target NameDehydrogenase inhibitor
• CAS No. 1432660-47-3
• Calculated MW 481.51
• Formulation C21H18F3N3O3S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:FC(F)(F)C1=CC(NC(=O)NC2=C(C=CC(=C2)S(=O)(=O)NC2CC2)C2=CSC=C2)=CC=C1
  Pathways:Metabolism
  Receptor:IDH2 R140Q mutant
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 96 mg/mL (199.37 mM); DMSO: 96 mg/mL (199.37 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wang F, et al. Science. 2013 May 3;340(6132):622-6.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting