• Product NameVGX-1027
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityVGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.
• Target NameIL Receptor inhibitor; TNF inhibitor
• CAS No. 6501-72-0
• Calculated MW 205.21
• Formulation C11H11NO3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:OC(=O)CC1CC(=NO1)C1=CC=CC=C1
  Pathways:Apoptosis; Immunology/Inflammation
  Receptor:IL-10; IL-1β; TNF-α
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 41 mg/mL (199.79 mM); DMSO: 41 mg/mL (199.79 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Stosic-Grujicic S, et al. J Pharmacol Exp Ther. 2007, 320(3), 1038-1049.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting