• Product NameDapivirine (TMC120)
• Brief DescriptionInhibitors
• Purification99.77%
• Biological ActivityDapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.
• Target NameHIV Protease inhibitor
• CAS No. 244767-67-7
• Calculated MW 329.4
• Formulation C20H19N5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1=CC(C)=C(NC2=NC(NC3=CC=C(C=C3)C#N)=NC=C2)C(C)=C1
  Pathways:Microbiology&virology; Proteases/Proteasome
  Receptor:HIV reverse transcriptase
  Boling pt:
  Melting pt:
  Solubility:DMSO: 34 mg/mL (103.21 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Van Herrewege Y, et al. Antimicrob Agents ChemOthers, 2004, 48(1), 337-339.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting