• Product NameGNF-2
• Brief DescriptionInhibitors
• Purification99.08%
• Biological ActivityGNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, shows no activity to Flt3-ITD, Tel-PDGFR, TPR-MET and Tel-JAK1 transformed tumor cells.
• Target NameBcr-Abl inhibitor
• CAS No. 778270-11-4
• Calculated MW 374.32
• Formulation C18H13F3N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:NC(=O)C1=CC=CC(=C1)C1=CC(NC2=CC=C(OC(F)(F)F)C=C2)=NC=N1
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:Bcr-Abl (K562 cell line); Bcr-Abl (SUP-B15 cell line)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 74 mg/mL (197.69 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Adrin FJ, et al. Nat Chem Biol, 2006, 2(2), 95-102

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting