• Product NameCGK 733
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.
• Target NameATM/ATR inhibitor
• CAS No. 905973-89-9
• Calculated MW 555.84
• Formulation C23H18Cl3FN4O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:[O-][N+](=O)C1=C(F)C=CC(NC(=S)NC(NC(=O)C(C2=CC=CC=C2)C2=CC=CC=C2)C(Cl)(Cl)Cl)=C1
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:ATM; ATR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (179.9 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Won J, et al. Nat Chem Biol, 2006, 2(7), 369-374.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting