• Product NameIOX 2
• Brief DescriptionInhibitors
• Purification99.81%
• Biological ActivityIOX2 is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).
• Target NameHIF/HIF Prolyl-Hydroxylase inhibitor
• CAS No. 931398-72-0
• Calculated MW 352.34
• Formulation C19H16N2O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:OC(=O)CNC(=O)C1=C(O)C2=CC=CC=C2N(CC2=CC=CC=C2)C1=O
  Pathways:Metabolism; Chromatin/Epigenetic
  Receptor:PHD2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 7 mg/mL (19.86 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tian YM, et al. J Biol Chem. 2011 Apr 15;286(15):13041-51.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting