• Product NameTGR5
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTGR5 Receptor Agonist, a potent TGR5(GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5).
• Target NameGPCR19 agonist
• CAS No. 1197300-24-5
• Calculated MW 361.22
• Formulation C18H14Cl2N2O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN(C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl)C1=CC=C(Cl)C=C1
  Pathways:GPCR/G Protein
  Receptor:TGR5
  Boling pt:
  Melting pt:
  Solubility:DMSO, Ethanol: 100 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Evans KA, et al. J Med Chem. 2009 Dec 24;52(24): 7962-5.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting