• Product NamePicropodophyllin (PPP)
• Brief DescriptionInhibitors
• Purification99.75%
• Biological ActivityReversine, a small synthetic purine analogue (2,6-disubstituted purine), is a potent inhibitior of Aurora A/B/C with IC50s of 150-500 nM.
• Target NameAdenosine Receptor antagonist; Aurora Kinase inhibitor
• CAS No. 656820-32-5
• Calculated MW 393.49
• Formulation C21H27N7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1CCC(CC1)NC1=NC(NC2=CC=C(C=C2)N2CCOCC2)=NC2=C1NC=N2
  Pathways:Cell Cycle/Checkpoint; GPCR/G Protein; Chromatin/Epigenetic
  Receptor:A3; Aurora A; Aurora B; Aurora C
  Boling pt:
  Melting pt:
  Solubility:DMSO: 5 mg/mL warmed (12.71 mM)
  Appearance:Purple Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. D'Alise AM, et al. Mol Y Ther. 2008, 7(5), 1140-1149.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting