• Product NameSAR245409 (XL765)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityVoxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
• Target NameDNA-PK inhibitor; PI3K inhibitor
• CAS No. 1349796-36-6
• Calculated MW 599.66
• Formulation C31H29N5O6S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC(OC)=CC(NC2=NC3=CC=CC=C3N=C2NS(=O)(=O)C2=CC=C(NC(=O)C3=CC(OC)=C(C)C=C3)C=C2)=C1
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:DNA-PK; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 12 mg/mL (20.01 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Garcia-Echeverria C, et al. Oncogene, 2008, 27(41), 5511-5526.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting