• Product NameBKM120 (NVP-BKM120, Buparlisib)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityBKM120 (NVP-BKM120, Buparlisib) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Phase 2.
• Target NamePI3K inhibitor
• CAS No. 944396-07-0
• Calculated MW 410.39
• Formulation C18H21F3N6O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:NC1=NC=C(C2=CC(=NC(=N2)N2CCOCC2)N2CCOCC2)C(=C1)C(F)(F)F
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:p110α; p110β; p110γ; p110δ; Vps34
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (4.87 mM); DMSO: 82 mg/mL (199.8 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Burger MT, et al. ACS Med Chem Lett, 2011, 2 (10), 774C779.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting