• Product NameBX795
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityBX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
• Target NameCDK inhibitor; Chk inhibitor; c-Kit inhibitor; PDK inhibitor
• CAS No. 702675-74-9
• Calculated MW 591.47
• Formulation C23H26IN7O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:IC1=CN=C(NC2=CC(NC(=O)N3CCCC3)=CC=C2)N=C1NCCCNC(=O)C1=CC=CS1
  Pathways:Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
  Receptor:CDK2/CyclinE; Chk1; c-Kit; PDK1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (169.07 mM)
  Appearance:White Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Feldman RI, et al. J Biol Chem. 2005, 280(20), 19867-19874.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting