• Product NameCX-6258
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCX-6258 is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity
• Target NamePim inhibitor
• CAS No. 1202916-90-2
• Calculated MW 461.94
• Formulation C26H24ClN3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)/C=C/4\C5=C(C=CC(=C5)Cl)NC4=O
  Pathways:Chromatin/Epigenetic; JAK/STAT signaling
  Receptor:Pim1; Pim2; Pim3
  Boling pt:
  Melting pt:
  Solubility:DMSO: > 10 mM
  Appearance:Orange Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mustapha Haddach, et al. ACS Med. Chem. Lett., 2012, 3 (2), pp 135-139

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting