• Product NameIbrutinib (PCI-32765)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPCI-32765(Ibrutinib) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.
• Target NameBTK inhibitor; Src inhibitor; Tyrosine Kinases inhibitor
• CAS No. 936563-96-1
• Calculated MW 440.5
• Formulation C25H24N6O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N
  Pathways:Angiogenesis; Proteases/Proteasome
  Receptor:BLK; Bmx; BTK; FGR; CSK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 88 mg/mL (199.77 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Burger JA1, Buggy JJ. Leuk Lymphoma. 2013 Nov;54(11):2385-91.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting