• Product NameAZD2932
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAZD2932 is a new series of quinazoline ether inhibitor which potently inhibits VEGFR-2 and PDGFR with IC50s of 4 nM/8 nM/ 7 nM for PDGFRβ/VEGFR-2/Flt-3.
• Target Namec-Kit inhibitor; FLT inhibitor; PDGFR inhibitor; VEGFR inhibitor
• CAS No. 883986-34-3
• Calculated MW 447.49
• Formulation C24H25N5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=C(OC)C=C2C(OC3=CC=C(CC(=O)NC4=CN(N=C4)C(C)C)C=C3)=NC=NC2=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:c-Kit; FLT3; PDGFRβ; VEGFR2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 5 mg/mL warmed (11.17 mM); DMSO: 89 mg/mL warmed (198.88 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pl PA, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting