• Product NameBX912
• Brief DescriptionInhibitors
• Purification98.29%
• Biological ActivityBX-912 is a selective inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1) with IC50 of 12 nM; >10 fold selectivity over PKA, PKC, C-Kit, EGFR etc.
• Target NameCDK inhibitor; Chk inhibitor; PDK inhibitor; PKA inhibitor; VEGFR inhibitor
• CAS No. 702674-56-4
• Calculated MW 471.35
• Formulation C20H23BrN8O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:BrC1=CN=C(NC2=CC(NC(=O)N3CCCC3)=CC=C2)N=C1NCCC1=CN=CN1
  Pathways:Angiogenesis; Cell Cycle/Checkpoint; GPCR/G Protein; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
  Receptor:CDK2/CyclinE; Chk1; PDK1; PKA; VEGFR2?(KDR)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 94 mg/mL (199.42 mM); DMSO: 94 mg/mL (199.42 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Feldman RI, et al. J Biol Chem. 2005, 280(20), 19867-19874.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting