• Product NameUNC0379
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityUNC0379 is a selective, substrate competitive inhibitor of N-lysine methyltransferase SETD8 with IC50 of 7.9 μM, high selectivity over 15 other methyltransferases.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1620401-82-2
• Calculated MW 413.56
• Formulation C23H35N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=C(OC)C=C2C(NCCCCCN3CCCC3)=NC(=NC2=C1)N1CCCC1
  Pathways:Chromatin/Epigenetic
  Receptor:SETD8
  Boling pt:
  Melting pt:
  Solubility:DMSO: > 10mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ma A, et al. J Med Chem. 2014, 57(15), 6822-6833.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting