• Product NameB-Raf IN 1
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityB-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM; equipotent against c-Raf (IC50= 25 nM).
• Target NameRaf inhibitor
• CAS No. 950736-05-7
• Calculated MW 515.53
• Formulation C29H24F3N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN(C)CC1=CC=C(C=C1)C1=C2N=CC=C(N2N=C1)C1=CC(NC(=O)C2=CC(=CC=C2)C(F)(F)F)=CC=C1
  Pathways:MAPK
  Receptor:B-Raf; C-Raf
  Boling pt:
  Melting pt:
  Solubility:DMSO: 40 mg/mL
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Berger DM, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting