• Product NameNecrostatin-1
• Brief DescriptionInhibitors
• Purification99.25%
• Biological ActivityNecrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
• Target NameTNF inhibitor
• CAS No. 4311-88-0
• Calculated MW 259.33
• Formulation C13H13N3OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN1C(=S)NC(CC2=CNC3=CC=CC=C23)C1=O
  Pathways:Apoptosis
  Receptor:RIP1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 51 mg/mL warmed (196.66 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Han W, et al. Apoptosis. 2009 May;14(5):674-86.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting