• Product NameMomelotinib (CYT387)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityCYT387(momelotinib) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3.
• Target NameJAK inhibitor
• CAS No. 1056634-68-4
• Calculated MW 414.46
• Formulation C23H22N6O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:O=C(NCC#N)C1=CC=C(C=C1)C1=NC(NC2=CC=C(C=C2)N2CCOCC2)=NC=C1
  Pathways:Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:JAK1; JAK2; JAK3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 74 mg/mL (178.54 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pardanani A, et al. Leukemia, 2009, 23(8), 1441-1445.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting