• Product NameZM 336372
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold selectivity over B-RAF, no inhibition to PKA/B/C, AMPK, p70S6, etc.
• Target NameRaf inhibitor
• CAS No. 208260-29-1
• Calculated MW 389.45
• Formulation C23H23N3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN(C)C1=CC=CC(=C1)C(=O)NC1=CC(NC(=O)C2=CC=C(O)C=C2)=C(C)C=C1
  Pathways:MAPK
  Receptor:C-Raf
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (5.13 mM); DMSO: 78 mg/mL (200.28 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hall-Jackson CA, et al. Chem Biol, 1999, 6(8), 559-568.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting